A2B receptor (aa2br_human)
FAMILY
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors A2B receptor
GENE
ADORA2B
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adenosine receptor A2b
SOURCE
SWISSPROT
SEQUENCE
N-term | TM1 | ||||||||
M
|
L
|
L
|
E
|
T
|
Q
|
D
|
A
|
L
|
Y
|
10 |
V
|
A
|
L
|
E
|
L
|
V
|
I
|
A
|
A
|
L
|
20 |
S
|
V
|
A
|
G
|
N
|
V
|
L
|
V
|
C
|
A
|
30 |
ICL1 | |||||||||
A
|
V
|
G
|
T
|
A
|
N
|
T
|
L
|
Q
|
T
|
40 |
TM2 | |||||||||
P
|
T
|
N
|
Y
|
F
|
L
|
V
|
S
|
L
|
A
|
50 |
A
|
A
|
D
|
V
|
A
|
V
|
G
|
L
|
F
|
A
|
60 |
I
|
P
|
F
|
A
|
I
|
T
|
I
|
S
|
L
|
G
|
70 |
ECL1 | TM3 | ||||||||
F
|
C
|
T
|
D
|
F
|
Y
|
G
|
C
|
L
|
F
|
80 |
L
|
A
|
C
|
F
|
V
|
L
|
V
|
L
|
T
|
Q
|
90 |
S
|
S
|
I
|
F
|
S
|
L
|
L
|
A
|
V
|
A
|
100 |
V
|
D
|
R
|
Y
|
L
|
A
|
I
|
C
|
V
|
P
|
110 |
ICL2 | TM4 | ||||||||
L
|
R
|
Y
|
K
|
S
|
L
|
V
|
T
|
G
|
T
|
120 |
R
|
A
|
R
|
G
|
V
|
I
|
A
|
V
|
L
|
W
|
130 |
V
|
L
|
A
|
F
|
G
|
I
|
G
|
L
|
T
|
P
|
140 |
ECL2 | |||||||||
F
|
L
|
G
|
W
|
N
|
S
|
K
|
D
|
S
|
A
|
150 |
T
|
N
|
N
|
C
|
T
|
E
|
P
|
W
|
D
|
G
|
160 |
T
|
T
|
N
|
E
|
S
|
C
|
C
|
L
|
V
|
K
|
170 |
TM5 | |||||||||
C
|
L
|
F
|
E
|
N
|
V
|
V
|
P
|
M
|
S
|
180 |
Y
|
M
|
V
|
Y
|
F
|
N
|
F
|
F
|
G
|
C
|
190 |
V
|
L
|
P
|
P
|
L
|
L
|
I
|
M
|
L
|
V
|
200 |
I
|
Y
|
I
|
K
|
I
|
F
|
L
|
V
|
A
|
C
|
210 |
R
|
Q
|
L
|
Q
|
R
|
T
|
E
|
L
|
M
|
D
|
220 |
TM6 | |||||||||
H
|
S
|
R
|
T
|
T
|
L
|
Q
|
R
|
E
|
I
|
230 |
H
|
A
|
A
|
K
|
S
|
L
|
A
|
M
|
I
|
V
|
240 |
G
|
I
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
V
|
250 |
H
|
A
|
V
|
N
|
C
|
V
|
T
|
L
|
F
|
Q
|
260 |
ECL3 | TM7 | ||||||||
P
|
A
|
Q
|
G
|
K
|
N
|
K
|
P
|
K
|
W
|
270 |
A
|
M
|
N
|
M
|
A
|
I
|
L
|
L
|
S
|
H
|
280 |
A
|
N
|
S
|
V
|
V
|
N
|
P
|
I
|
V
|
Y
|
290 |
H8 | |||||||||
A
|
Y
|
R
|
N
|
R
|
D
|
F
|
R
|
Y
|
T
|
300 |
F
|
H
|
K
|
I
|
I
|
S
|
R
|
Y
|
L
|
L
|
310 |
C
|
Q
|
A
|
D
|
V
|
K
|
S
|
G
|
N
|
G
|
320 |
C-term | |||||||||
Q
|
A
|
G
|
V
|
Q
|
P
|
A
|
L
|
G
|
V
|
330 |
G
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
adenosine
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page